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Triumeq copay card 201812/6/2023 ![]() ![]() Clinically, it is not possible to determine whether a hypersensitivity reaction with TRIUMEQ or TRIUMEQ PD would be caused by abacavir or dolutegravir.Hypersensitivity reactions have been reported with dolutegravir and were characterized by rash, constitutional findings, and sometimes organ dysfunction, including liver injury.Warnings and precautions Hypersensitivity Reactions: Do not use TRIUMEQ or TRIUMEQ PD in patients with moderate or severe hepatic impairment. ![]() Do not use TRIUMEQ or TRIUMEQ PD in patients receiving dofetilide.Do not use TRIUMEQ or TRIUMEQ PD in patients with previous hypersensitivity reaction to abacavir, dolutegravir, or lamivudine.Do not use TRIUMEQ or TRIUMEQ PD in patients who have the HLA-B ✶5701 allele.Monitor hepatic function closely in these patients and, if appropriate, initiate anti-hepatitis B treatment Severe acute exacerbations of HBV have been reported in patients who are co-infected with HBV and HIV-1 and have discontinued lamivudine, a component of TRIUMEQ and TRIUMEQ PD.If TRIUMEQ or TRIUMEQ PD is used in patients co-infected with HIV-1 and HBV, additional treatment should be considered for appropriate treatment of chronic HBV otherwise, consider an alternative regimen Emergence of lamivudine-resistant HBV variants associated with lamivudine-containing antiretroviral regimens has been reported. All patients with HIV-1 should be tested for the presence of hepatitis B virus (HBV) prior to or when initiating TRIUMEQ or TRIUMEQ PD.Following a hypersensitivity reaction to TRIUMEQ or TRIUMEQ PD, NEVER restart TRIUMEQ or TRIUMEQ PD or any other abacavir-containing product.Discontinue TRIUMEQ or TRIUMEQ PD immediately if a hypersensitivity reaction is suspected, regardless of HLA-B ✶5701 status and even when other diagnoses are possible.All patients should be screened for the HLA-B ✶5701 allele prior to initiating therapy or reinitiation of therapy with TRIUMEQ or TRIUMEQ PD unless patients have a previously documented HLA-B ✶5701 allele assessment TRIUMEQ and TRIUMEQ PD are contraindicated in patients with a prior hypersensitivity reaction to abacavir and in HLA-B ✶5701-positive patients.Patients who carry the HLA-B ✶5701 allele are at a higher risk of experiencing a hypersensitivity reaction to abacavir, although hypersensitivity reactions have occurred in patients who do not carry the HLA-B ✶5701 allele.Serious and sometimes fatal hypersensitivity reactions, with multiple organ involvement, have occurred with abacavir-containing products.BOXED WARNING: HYPERSENSITIVITY REACTIONS AND EXACERBATIONS OF HEPATITIS B VIRUS (HBV) Hypersensitivity Reactions:
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